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The detector demonstrates linearity in dose rate up to 100 Gy/min and position resolution of 0.42 mm.
Washout of radon progeny by rainfall is the most important cause of natural variations in dose rate.
Several characteristics of the monitor's performance were studied, including linearity in dose rate, reproducibility, recombination correction, and dependence on both radiation field size and gantry angle.
This could in part be explained by the profound differences in dose rate; dose rate effects on the transcriptional response have previously been described in vivo following radionuclide administration [22, 25, 29].
The three parameters having the most influence on dispersion in dose rate distributions, and modelled in this study, appear to be grain size, potassium content and total dose rate.
The increase in dose rate at a given time is a function of the amount of progeny decaying, which in turn is a balance between deposition of progeny by rainfall and radioactive decay.
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Moreover, the questionnaire revealed that errors in dose rates were common.
However, most of the population live at relatively low altitudes (see below), so it is reasonable to assume the variation in dose rates seen in the analysis is mostly due to terrestrial gamma rays.
While the ability to compare toxicities among the published clinical trials evaluating toceranib in dogs with cancer is limited due to variability in dose rates and dosing schedules used, it does appear that the use of lower doses of drug are associated with significantly fewer grade 3 and 4 AEs.
A novel method is presented for the rigorous propagation of uncertainties in initial concentrations and in dosing rates into the errors in the rate constants fitted by multivariate kinetic hard-modelling of spectroscopic data using the Newton Gauss Levenberg/Marquardt optimisation algorithm.
The Monte Carlo transport code, MCNP, has been applied in simulating dose rate distribution in the IR-136 gamma irradiator system.
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