Sentence examples for in dose finding from inspiring English sources

As the efficacy index for garenoxacin as well as other quinolones, AUC/MIC ratio was deemed appropriate for use in dose finding [ 9].

Some safety signals observed in dose finding studies with new drugs (i.e., rash with BI 201335, hypertransaminasemia with unboosted danoprevir) suggest the need for a careful evaluation of side effects in phase III studies.

The presence of patient heterogeneity in dose finding studies is inherent (i.e. groups with different maximum tolerated doses).

Biometrics 48, 853 862], O'Quigley and Shen [1996. Continual reassessment method: a likelihood approach. Biometrics 52, 163 174], O'Quigley et al. (1999), O'Quigley et al. [2002. Non-parametric optimal design in dose finding studies. Biostatistics 3, 51 56], O'Quigley and Paoletti [2003. Continual reassessment method for ordered groups. Biometrics 59, 429 439], Piantodosi et al., 1998.

In dose finding studies with more than one treatment arm we always used the treatment group with the highest efficacy.

The objective parameters measured by thromboelastography would have been helpful not only in controlling efficacy of rFVIIa but also in dose finding decisions.

An extension of the continual reassessment method using a preliminary up and down design in a dose finding study in cancer patients in order to investigate a greater number of dose levels.

In view of the response rate of 52% observed in this dose finding study we performed a phase II study to further confirm the safety and activity of this bi-weekly regimen.

Overall, the manageable tolerability profile and the encouraging activity in this dose finding study support further clinical development of this combination for treatment of solid tumours.

In our dose finding assays, we evaluated the impact of a wide dosing range (1, 3, 6, 12, 24 and 48 mg/ml) of lamotrigine on fly mortality (data not shown).

To avoid potential underdosing of patients with breast cancer, initial s.c. dose finding in part 1 was conducted in healthy male volunteers.