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Changes in dose distribution due to relocation of catheters were evaluated using DVHs.
It was shown that manufacturing differences of brachytherapy seed cause considerable changes in dose distribution.
To test the calibration, a 2 Gy test run was successfully performed on a tube filled with water with an accuracy of 3% in dose distribution.
The LINAC was also calibrated in order to distribute the most homogenous dose to the sample tubes and the result showed a 3% variation in dose distribution.
However, patients with a high risk for a certain, severe, morbidity symptom may require a change in dose distribution or in treatment strategy, or follow-up protocols may need to be adjusted to the individual morbidity risk pattern based on early biomarker expression.
However, tumor motion may have significant impact in dose distribution.
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We then calculated dosimetric parameters and compared results with simulated treatment plans for stereotactic body radiotherapy (SBRT), using dose--volume histograms to clearly explain differences in dose distributions between PT and SBRT.
Several studies have been conducted concerning the dosimetry of narrow photon beams in a homogeneous medium [2] [7], but the influence in dose distributions of bone equivalent materials in such beams is the subject of only a few papers [8] [14].
Improvements in dose distributions with margin reductions have been reported for many tumors, but not for NPC.
IMRT planning using advanced treatment planning algorithms and powerful computers results in dose distributions conforming to the shape of the target with steep dose fall-off outside the target.
Most NPC patients will experience changes in anatomic structures due to obvious tumor shrinkage and/or weight loss [ 6], which leads to varying degrees of deviation in dose distributions to both tumors and organs at risk (OARs).
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