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The importance of the magnitude of uncertainties in dose assessment is considered.
Intercomparison design along with alanine performances analyzing the different contributions to the combined uncertainty in dose assessment are reported.
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There are now several examples of the use of PBPK models during the drug discovery and development phases for decision-making specific to candidate selection, first-in-human dose, assessment of DDI potential, and definition of appropriate study designs involving DDIs or inclusion/exclusion criteria for studies with drugs metabolized by polymorphic enzymes.
Drugs where body weight is important in the dose assessment are often prescribed without a recorded weight.
Our study offered advancement in individual internal dose assessment based on residential THM levels, detailed water use behaviors and exposure during pregnancy.
In transcriptomics studies, FDXR gene is known as one of the most radiation responsive markers27,28 and has been validated as a sensitive gene for dose assessment in two large scale studies on laboratory inter-comparison of gene expression5,29,30.
Finally, CT radiation dose from hybrid imaging systems was addressed by giving some examples of dose assessment in the limited context of anatomical localization and attenuation correction.
To investigate dose impact owing to neglect of the metal shielding effect, Monte Carlo (MC) simulation, BPS calculation, and film measurement have been performed for dose assessment in a water phantom.
[1] Stabin, M. G., Sparks, R.B., Crowe, E. OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine.
Most studies use the calculated exposure factors as obtained from the scan parameters for dose assessment; in the study of Biswas et al. [2] the dose was actually measured.
The available guidance for activities following nuclear accidents is limited with regard to strategies for dose assessment in health risk studies.
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CEO of Professional Science Editing for Scientists @ prosciediting.com