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The proposed method was successfully applied to the analysis of the drug in dosage form.
The practically insoluble nature of IBR creates several problems in dosage form design of IBR.
Moreover, results close to 100% were obtained for the determination of NF in dosage form, Table 6.
The above mentioned methods were applied for analysis of AML, OLM and HCT in dosage form (Tribenzor® tablets).
Poor dissolution performance is one of the challenges encountered in dosage form design of amorphous solid dispersions (ASDs).
Table 4 Application of the proposed and comparison methods to the determination of the studied drugs in dosage form Parameter The proposed method Comparison method 35) Conc.
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The proposed method was successfully applied to the analysis of the cited drugs in dosage forms.
Both of USP and BP recommended HPLC method with UV detection at 263 nm for its determination in dosage forms.
It was performed through repeated analysis of variable concentrations of EBS either per se or in dosage forms on four successive days.
The repeatability was evaluated through analysis of different concentrations of the studied drug in pure or in dosage forms on 4 successive times.
The repeatability was evaluated through the replicate analysis of different concentrations of EBS samples, either in pure or in dosage forms.
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