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This is consistent with the critical importance of this cytokine in diverse models of fibrosis in various tissues.
Manipulation of the unfolded protein response (UPR), a major homeostatic reaction under ER stress conditions, had proved beneficial in diverse models of neurodegeneration.
In vivo, PI3Kγ−/− mice have been shown defective in diverse models of inflammation, including acute peritonitis [8], [9] and delayed type hypersensitivity [19].
Direct incorporation of BM-progenitor cells has been extensively shown in diverse models [24] but the low and variable frequency at which BM-progenitors are found incorporated into vessels is suggestive of an indirect (possibly paracrine or justacrine) role during the neo-angiogenesis processes.
Our goal in the current study was to investigate, in parallel, the effects of RIP1 and RIP3 blockade in diverse models of acute liver injury.
Several studies have explored whether reduction in cAMP production in diverse models of murine cardiac disease are accompanied by changes in cAMP-hydrolytic capacity.
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The study of PUF proteins in diverse model organisms revealed widespread roles for these proteins in embryonic development, stem-cell maintenance and neurogenesis [10], [11].
The data supporting this model were obtained in diverse model systems, using ectopic telomere length modulation or TERRA regulation.
The methods presented in this communication should be of interest to many investigators working in diverse model systems.
Studies in diverse model organisms have shown that impairment of TOR signaling leads to increased life span.
Yet automatic comparisons are increasingly necessary, with large amounts of functional data generated in diverse model organisms.
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