This can result in divergent functions of orthologous genes, thus varying phenotypes of the same mutations.
Such duplication might result in split or divergent function of the gene (Yamamoto and Vernier, 2011).
Moreover, some duplicated paralogous genes showed divergent function in the evolutionary process, even though the reasons for expression divergence of the duplicated genes in many gene families remain unclear.
Together, these data indicate that fish-specific duplicated dmrt2b contributes to a divergent function in somitogenesis through Hedgehog pathway and maintains the common function for left-right asymmetry establishment.
Then, we demonstrate that Dmrt2b contributes to a divergent function in somitogenesis through Hedgehog pathway, because Dmrt2b knockdown reduces target gene expression of Hedgehog signaling, and also impairs slow muscle development and neural tube patterning through Hedgehog signaling.
The duplicated ortholog pairs of BdMAPK cascade kinase genes revealed their convergent or divergent function in the process of evolution.
Base on the regulation network, we found that most of duplicated BdMAPK cascade kinase gene orthologs showed their convergent function, whereas few of them developed divergent function in the evolutionary process.
The network of co-expression regulation showed the most of duplicated BdMAPK cascade kinase gene orthologs demonstrated their convergent function, whereas few of them developed divergent function in the evolutionary process.
While C. dubliniensis crz1/crz1, crz2/crz2, and crz1/ crz1 crz2/ crz2 double mutants grew similarly to wild-type in the presence of TM, the C. albicans crz1/crz1 mutant exhibited attenuated growth that was intermediate between wild-type and calcineurin mutants (Figs. 1 and 2), indicating a divergent function of Crz1 in ER stress responses in both Candida species.
These differences in their expression patterns suggest divergent functions in transcriptional activity and cell differentiation between Pax1b and Pax9 in zebrafish.
