Sentence examples for in diseases models from inspiring English sources
Important to synucleinopathies, activation of the UPR seems to be an early event in the pathogenesis of PD [ 153, 154] and MSA [ 155], a finding that can be recapitulated in diseases models in vitro and in vivo[ 156– 156].
Comprehensive pre-clinical studies aimed at establishing effectiveness of TAS2R agonists in disease models are lacking.
This novel antioxidant can be applied to investigate oxidative stress in disease models, like α-synucleinopathies and other neurodegeneration models.
We therefore selected the lowest 2 doses for investigating the utility of XPO1 inhibition in disease models.
However, the cardiac protective effect of PDE3A has not been demonstrated in vivo in disease models.
KAR5585 was selected for further pharmacological evaluation in disease models associated with a dysfunctional peripheral 5-HT system.
Recombinant lentiviral vectors (LVs) are highly effective vaccination vehicles that elicit protective T cell immunity in disease models.
That triggers high fluid pressure inside tumors, which in turn hinders effective transit of drugs out of blood vessels and into the spaces between the tumor cells, explains Lisa Coussens, senior author of the study, published in Disease Models and Mechanisms.
In light of our data demonstrating a mild neuroprotective effect of SINE compounds independent of their effects on nucleocytoplasmic transport, these observations provide additional evidence that SINE compounds likely act through alternative mechanisms to relieve toxicity in disease models.
Further studies to understand the pharmacokinetics of ribitol in disease models and metabolic pathways of the pentose alcohol to CDP-ribitol would also allow us to optimize the dosage and delivery regime for higher efficacy.
The paper reports that when these drugs were tested in disease models, the cancer cells showed a dramatic response, suggesting promising strategies for the treatment of the HR-/HER2+ cancer subtype.
