In addition, advances in SPR technology, with the development of multiplexing multichannel instruments, could help resolve some of the difficulties in binder specificity not relating to toxicity.
It is this complexity which explains the difficulty in the development of effective strategies for prevention of cognitive impairment in people with diabetes and in the development of treatment approaches in those patients who have already become cognitively impaired.
All atypical BSE-infected cattle developed difficulty in rising, which usually coincided with the development of gait deficits (see Figure 1), predominantly hind limb hypermetria [see Additional files 1: 'H-type BSE (H1)', 2:' L-type BSE (L1)' and 5: 'H-type BSE (H4b)' showing all animals with difficulty in rising (score 2) prior to cull; hind limb hypermetria is also evident in L1].
Recently, the difficulty in microbial research has been overcome with the development of SCS.
The unexplained weakness together with the development of difficulty in swallowing due to reduced salivation (requiring saliva substitute every four hours, modified barium swallow evaluation was normal), difficulty in urination, constipation, and rather unexplained postural tachycardia prompted investigations for neurological autoimmunity.
Increased hyperactivity is associated with the development of educational difficulties especially in reading [ 72].
Thinking, she showed, could keep evil at bay, but only in the abstract, not, or only with great difficulty, in the historical development and context of Nazism.
However they do have delays in acquisition of motor skills, difficulty with fine motor tasks, visual and visuospatial difficulties, some delay in the development of speech and language, learning and behavioural difficulties and sub-optimal head growth [ 10- 12].
The difficulty with the Bush proposal lies in the details.
Mr. Kwan's award-winning work in earlier films heavy on acting and character development attracted the actor Hu Jun, a matinee idol in China, to the part of Handong despite his initial difficulty with the homosexual content.
