Although regimens consisting of gemcitabine in combination with erlotinib or capecitabine have shown statistically significant increases in survival duration, the small amount of survival benefit and accompanying toxicities result in difficulties related to their translation into clinically meaningful improvements (Cunningham et al, 2005; Moore et al, 2007).
(Anencephaly is a case in point regarding the difficulties relating time trends in frequency of occurrence of particular malformations in the Basra data with population data from the West.
Written in 1616, when difficulties relating to natural theology first began to amass around Copernican and Galilean doctrines, and printed in Frankfurt in 1622, the Apologia represents an act of great courage and intellectual honesty on Campanella's part, since he took up this delicate issue while he was still in prison and, furthermore, was not even defending his own doctrines.
Toxicology researchers may also work directly with crude or partially purified extracts of toxic cyanobacteria in order to overcome difficulties relating to availability of purified toxins.
Nikbakht found that Iranian nurses were confronted with many difficulties in two domains: (1) difficulties relating to work settings, such as personnel shortages, heavy workloads, unclear tasks, lack of registered and auxiliary nurses, equipment deficiencies and low salary; and (2) difficulties relating to a poor public image and a low social status of nurses [ 29].
The efficacy and safety results of the EINSTEIN PE and EINSTEIN-Extension study, and the more convenient treatment with rivaroxaban or any other approved NOAC will likely impact on the clinical decision to stop or continue anticoagulation treatment, e.g. in patients in whom difficulties related to VKA management drive the decision to stop anticoagulation despite a high risk of recurrent VTE.
Attachment disorders, specifically Reactive Attachment Disorder (RAD) and Disinhibited Social Engagement Disorder (DSED) are disorders associated with neglect and abuse in which people have significant difficulties relating to others.
All studies carried out on data registered in compulsory disease notifications confront difficulties relating to under-notification and diagnostic error when such diagnoses are based only on suspected cases: clinical signs and symptoms and epidemiological connections [ 18, 19].
FGIs were selected because they enable the exchange of frank opinions between colleagues with similar roles and are effective in revealing inner difficulties related to teaching in clinical practice.
In community settings, difficulties relate to vehicle use and home visiting.
