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Whether the epidemiologic differences are due to differences in transmission in differing populations or because of the effectiveness of public health responses is difficult to gauge.
These issues can be partially addressed by validation efforts in differing populations or split-sample approaches, derivation of simplified patterns, and thorough descriptive analyses.
Several studies in differing populations have identified a variety of clinical factors associated with AVF FTM, such as age ≥65 years [ 12], female gender [ 13], uraemia [ 14], diabetes, peripheral vascular disease (PVD) and non-white race [ 15].
Three phase IIIa studies compared the efficacy and safety of Gla-300 with insulin glargine 100 U/ml (Gla-100) in differing populations of people with T2DM 4– 6.
Similar(56)
In presence of genetic heterogeneity, disease disposing loci may differ in different populations or cohorts.
Third, environmental determinants may differ in different populations, partly depending on the genetic architecture.
However, the cut-off for depression may differ in different populations.
For example, the genetic changes underlying identical adaptations in different populations can differ, even if in minute detail.
This difference could be due to the differing populations especially in relation to age.
However, these associations are frequently based on case reports, in differing patient populations with multiple medication exposures and using various definitions of ILD.
Inaccuracies could also be caused by authorities in different countries looking at differing population groups.
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