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Marsupials and eutherian species, independently, found it advantageous to separate class Ia genes from antigen processing genes, resulting in differing class I organization between these lineages of mammals, but effectively the same outcome, multiple class Ia genes.
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Depending on the EC classes, there are sometimes cases where the order of layers should be changed for better precision, reflecting the fact that the classification criteria differ in different classes.
Moreover, the reactions these genes' proteins catalyze have not changed since, although the location, timing and function of these reactions can differ greatly in different classes or phyla.
Variance within class in real-life datasets, unlike variance within class in toy datasets (which is fixed at 1 in this study), differs from class to class even within the same dataset, and is likely to be larger than 1.
We have demonstrated that, in contrast with their expression in cell lines of differing origins, class IA PI3K adaptor, p85, and class II PI3K enzymes display a specific and selective tissue distribution.
Recently, we reported the surprising finding that chromatin structure does not actively regulate transcription of the class I gene: nucleosomal occupancy and positioning are indistinguishable in tissues that differ in class I expression levels by an order of magnitude and do not vary upon either induction or inhibition of transcription.
Their distribution and other features of the operons suggest that their roles in energy conservation differ in Class I methanogens, Methanosarcinales, and Methanomicrobiales.
Class #3 differed from class #1 in two respects.
Class 3 differed from class 1 in the low probability of non-digestive symptoms (S9-S11).
Members of the different classes differ in a number of ways and in particular those with two internal repeats show the properties expected of fairly recently transposed SINEs - they are the most homogeneous in length and sequence, they have the longest (i.e. the least decayed) target site duplications and are the most likely to show evidence (in a cDNA library) of active transcription.
In such conditions, organization is encountered with multi-class dynamic PERT networks, while projects from different classes differ in their precedence networks, the mean of their service time in every service station, and also their arrival rates.
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