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The importance of histone variants during development and in differentiated states is also emerging.
Increasing oxygen tension reduces the state fluctuations in differentiated states, thereby inducing unspecific differentiated, non-proliferative cells.
Hence, a differentiation-inducing environment reduces noise in high α states causing an accumulation of cells in differentiated states (see Figure 1a).
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In differentiated state, they mimic typical characteristics of the human small intestinal epithelium, like a well-developed brush border with associated enzymes such as alkaline phosphatase and sucrase isomaltase [ 6].
The incoherent genes may behave so due to environmental interactions, differences in cell culture system or in the differentiated states being compared.
On the contrary, wild-type cartilages, which contain a mixture of cells in progressively more differentiated states, some of which already lost cell-cell contacts, expressed significantly lower levels of β-catenin and cadherins.
In this section, we examine the behavior of a cell initially in a differentiated state to removal of differentiation stimulus, and investigate a role for stochasticity in triggering transitions from a differentiated state to the pluripotent state.
It is not clear whether variations in antigen expression reflect variations in the differentiated state of the cells or merely variations in the carbohydrate structures on otherwise identical cells, nor is ir clear whether antibodies could be made that bind to all tumour cells by avoiding antibodies to carbohydrate structures.
The extracellular matrix (ECM) contributes to the control of the cellular function and is involved in maintaining the cells in a differentiated state [29], [30].
The constitutively active CMV promoter enables transgene expression in all cell types in both undifferentiated and differentiated states.
Both cell lines stained positive for the presence of MUC1* in the undifferentiated state, but not in the differentiated state (data not shown).
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