Several self proteins have been suggested as disease-driving autoantigens, and the presence of autoantibodies with different specificities in patients with RA (reviewed in [ 1, 2]) supports the hypothesis of an autoimmune aetiology.
In addition, TZDs have different specificities for PPARs.
Although the different classes of HDACs share a certain degree of sequence homology, they exhibit different specificities in various systems [14] [17].
Therefore, the increased expression of CelK and CbhA suggests an enhanced need for exo-exo synergy between these two classes of exocellulases, with different specificities, in cells grown on natural plant biomass to attack the cellulose in this complex substrate from both reducing and non-reducing ends [58].
Thus, the second sulphate might mark an ancient second (allosteric) binding site that has evolved different specificities in different AGO homologues (for example, for the cap structure, GW182 or other ligands).
This method enabled us to analyze for up to 27 different specificities in each sample (two examples of this staining method are provided in Supplementary Figure S2).
The intracellular tyrosine kinase domain of ErbB receptors is highly conserved, while the extracellular domains are less conserved among the four receptors, suggesting different specificities in ligand binding.
Our results show that while p300 and CBP acetylate many common residues on H3 and H4, they do in fact possess very different specificities, and these specificities are dependent on whether histone or acetyl-CoA is limiting.
This systemic connective tissue disease is characterized by progressive fibrosis of the skin and internal organs; the presence of antinuclear antibodies (ANA) is frequently found in the serum with different specificities for nuclear targets [ 41].
In short, MHC monomers were multimerized with two different streptavidin conjugates for each peptide specificity, enabling the simultaneous testing of 36 different specificities in a single sample by combining nine colors into dual-color codes for MHC multimers, in order to measure specific T-cell populations with flow cytometry.
