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Apart from lamin, which is the common substrate for Gra-A, Gra-B and caspase-3, PARP-1 is also cleaved by these 3 proteases resulting in different fragmentation patterns [ 66, 145- 147].
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In practice, different fragmentation pathways may lead to fragments with identical molecular structure.
In this respect, the different fragmentation pathways in CAD and EDD offer a crucial advantage.
In addition, mechanisms explaining the different fragmentation of alkylated oligonucleotides in the mass spectrometer and in solution are provided.
In this work, we compare the different fragmentation techniques and MS detection in a linear ion trap and the ICR cell with respect to their abilities to efficiently identify and characterize phosphorylated peptides.
The possible mechanism for different fragmentation pathways in positive polarity was discussed.
On the basis of the obtained results, we are planning to design LC time-scale compatible, data-dependent MS/MS methods using the different fragmentation techniques in order to improve the identification and characterization of phosphopeptides.
An obvious deforestation was observed during 1954 2000, with two different fragmentation processes in two periods: the first fragmentation process from 1954 to 1976 was mainly observed along the ecotone between forest and other landscape classes while the second fragmentation process from 1976 to 2000 was observed both in the ectone and interior area of forest patches.
An improved version of the ProSight search engine, capable of database retrieval on the different sets of ions generated by the different fragmentation techniques in the same search, completes the search.
To compare the effect of different fragmentation softening grids in femtosecond laser assisted cataract surgery on effective phacoemulsification time (EPT).
Due to the previously mentioned disparities in the proteins identified by the different fragmentation techniques, it is necessary to directly compare their cleavage propensities from the same protein.
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