For an ICC of 0, the size of the treatment effect is the same for both approaches (as in this case, there is no difference between patients in different centres, and so both approaches are answering the same question).
Variable data processing of 18F-FET PET in different centres leads to significant differences especially for TBRmax and Tvol.
Despite major advances in perioperative blood conservation, the transfusion rate in heart surgery patients remains high and large differences can be observed in different centres [ 16].
There is some controversy about the diagnostic accuracy of TAC analysis for tumour grading raising the question whether discrepant results in different centres may be caused by differences in the methodology, patient population or other reasons such as neuropathological interpretation.
As is the case when there are several groups working in the field, it becomes difficult to compare studies carried out in different centres using xenografts arising from cells at differing passage numbers in different mouse models.
The analysis was further refined by using a constant comparison of themes, and looking for negative cases in order to examine for similarities and differences within and between the patients' perception and observations in different centres.
A recent UK audit of test results from 18 TEG® and 10 ROTEM® users, in different centres, found sufficient variation in results to suggest that differences in therapy would have resulted.
Different studies have used different components in the TTCW definition and there are major potential local differences in practice that may make a measure unworkable or unreliable in different centres.
Once the structure of DNA was described by Crick and Watson in 1953, it took many years, and numerous scientists working in different centres, to understand the genetic code.
The establishment of an internationally accepted unit of measurement at Stockholm in 1925, the roentgen unit, enabled physicists to undertake similar calibration in different centres and provided a means of devising a system of dosimetry.
More than 22000 people are working in different centres to supply this service.
