Exact(3)
Furthermore, the advantage of Illumina to provide 30-times more reads would enable us to perform in depth sequencing of hundreds of samples in one run at a fraction of the costs, making it an excellent tool for large microbiome studies.
In depth sequencing of LTA4H-coding regions in subjects carrying HapK or rs2540477 may help to identify putative amino acid substitutions that are in linkage disequilibrium with these variants and/or alternatively spliced isoforms and lead to increased LTB4 production.
Nevertheless, BAC end sequencing does provide a quasi-random sampling of the genome and carries with it the advantage that BAC clones that appear to contain targets of interest provide excellent material for other analyses such as fluorescent in situ hybridization (FISH) to metaphase or pachytene chromosomes or in depth sequencing for gene discovery.
Similar(57)
To comparatively analyze the human microRNAomes between normal pregnant and miscarriage deciduas by an in-depth sequencing of microRNA (miRNA); and to specifically examine miRNA-199b-5p miRNA-199b-5p miRNA-199b-5pgulandd kinaserum/glucocorticoidand in vitregulatedeir possible roles in pregnancy maintenance.
Using MIRA coupled with 454 sequencing, we demonstrated a highly efficient capture of methylated DNA followed by in-depth sequencing of a large number of CpG islands.
Contemporary in-depth sequencing of environmental samples has provided novel insights into microbial community structures, revealing that their diversity had been previously underestimated.
This first in-depth sequencing analysis of nifH genes in marine surface waters generated a wealth of new data and novel insights into the diversity and composition of diazotrophic plankton.
In this first in-depth sequencing of nifH PCR amplicons from marine waters, we document a large diversity and spatial variation of putative diazotrophs and a striking dominance by members of the Phylum Proteobacteria.
Therefore we expect that expanding this multigenic approach using in-depth sequencing of other sets of genes, particularly other hubs within the synaptic proteome, will identify other nsSNP clusters, and genetic load that may define a range of neuropsychiatric diseases [19].
Identification of this additional variation would require additional SNPs and perhaps in-depth sequencing.
Whether this is representative of other Dipteran genera requires more in-depth sequencing of other genera.
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