This paper presents in-depth methodological analysis and optimization of two currently available HPLC procedures (Lennard Singleton [J. Chromatogr. 583 (1992) 83] and Dervieux Boulieu [Clin. Chem. 44 (1998) 551]) to improve precision, turn-around time, ruggedness, and cost effectiveness.
We believe this is the first in-depth methodological systematic review of meta-ethnography conduct and reporting.
Sir–We thank Dr. Xie and his colleagues for their great interest in performing such an in-depth methodological assessment of our article (Cheng et al. 2014).
The exploratory in-depth methodological nature of the multimethod trial necessitated that sites be few (2), similarly staffed and sized (Facility A, 32-bed; Facility B, 40-bed), and have strong administrator support.
Nonetheless, we believe that our review has revealed important insights into current use of this interpretive qualitative synthesis approach and that it is the first in-depth methodological systematic review of meta-ethnography conduct and reporting.
For more in-depth methodological explanations of these and other environmental economic methods see, for example, Champ et al. (2003) or Tietenberg and Lewis (2011); other examples have been published in the health economics literature (e.g., Culyer and Newhouse 2000; Drummond et al. 2005).
To conduct a fair and in-depth comparison, a methodological approach is pursued using exhaustive grid searches for model selection assisted by sensitivity analysis.
Because a case study allows closely observing happenings and listening to participants and their perspectives via in-depth interviewing, the methodological approach of a case study was a good epistemological fit and served the purpose of this study.
It is emphasised that an in-depth knowledge of methodological advances (and existing tools) is vital if researchers are to design and implement appropriate programs with the ability to adequately address the vast range of research questions pertinent to CAM.
Morphological expertise and data are in short supply relative to their molecular counterparts (de Carvalho et al., 2008), preventing in-depth analyses of methodological and biological drivers of conflict.
A chronological overview of selected major milestone studies was obtained to demonstrate the development of child psychiatric epidemiology, with a more in-depth discussion of findings and methodological issues exemplified in one cohort, the Generation R Study.
