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Even in the absence of an in depth functional validation of the mutant, the transcriptome based MapMan analysis helps us to rapidly identify the potential candidate genes and pathways associated with DXR.
Quantitative information on site-specific S-nitrosation is necessary for in depth functional studies.
Future studies using more in depth functional studies and other organisms will be needed to support this hypothesis.
Thus, our study supports the notion that the EpCAM signalling pathway is involved in GC biology, and RIP merits further attention and, in depth, functional studies in GC.
The following topics were covered in depth: functional screens and sequencing, hormones, lineage tracing, the propagation of human breast tumours as xenografts and tumour-stroma interactions.
The studies on ADAM7/TACE are very preliminary and in depth functional studies need to be done to evaluate the significance of this result.
Similar(51)
Where multiple candidate genes require testing, the constraints of mouse bioassays become prohibitive necessitating the development of a fast, reliable, ethical and cost-effective in-vitro screen to provide a measure of prion-related function to assist with prioritization for in-depth functional genomics.
However, because of their poor genetic tractability, including transformation, truffles have so far eluded in-depth functional genomic investigations.
The methodology for testing the sites for this particular report includes one simple API call plus check for a valid result, which means that it's not exactly an in-depth functional test of the full APIs, but could still be used to evaluate whether one should rely on certain APIs for business purposes.
In-depth functional studies are, however, required to examine how this gene interactively exerts its effects in humans.
Since these proteins have previously been implicated in cancer [45], [46], their suppression in ESFT may deserve in-depth functional studies in the future.
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