Sentence examples for in defined stages from inspiring English sources

Development of the mammary gland is initiated with the formation of a small ductal tree in the embryo but progresses predominantly after birth in defined stages associated with sexual development and reproduction, including prepuberty, puberty, pregnancy, lactation, and involution.

Firstly, they observed that tissues formed from ECCs differentiated in vitro retained a degree of structural organisation reminiscent of normal embryonic development, and secondly they noted "that the processes of cell determination and differentiation occur in defined stages which are accessible to experimental analysis and manipulation".

c-Met activity is normally detected in defined stages of embryogenesis and organogenesis [ 2- 7].

The mammary gland begins to form early during embryogenesis and continues to develop in defined stages that are correlated with sexual development and reproduction [ 40- 42].

Although MRC guidance on evaluating complex interventions [ 3] provides a useful framework for the successful conduct of trials of this sort, the evolution of interventions in healthcare and their subsequent evaluation does not always proceed in clearly defined stages.

In addition, defined stages of tumor development, breeding conditions, and blood sampling can all be controlled and standardized to limit heterogeneity.

In general, biomarker validation studies require demonstrating validity in three broadly defined stages, in which the following concerns are addressed: (i) analytical issues [ 8, 47, 48]; (ii) inter- vs intra-personal biological variation; and (iii) utility (ie, the correspondence of a certain biomarker profile with a phenotype of interest) [ 4, 7, 49- 57].

Beyond the 100% incidence of arthritis, another major advantage of the AIA model is that the time point of induction of arthritis is known, allowing manipulation of CD4+CD25+ Treg cell number in vivo at defined stages in the disease.

(iii) IR-induced specific ghrelin signals were exclusively observed in spermatogonia at defined stages of the seminiferous epithelial cycle (at stages II VIII).

The advantage of AIA over other experimental arthritis models consists in the exactly defined stages of the development of arthritis elicited by antigen injection into the knee joint cavity.

The present study was designed to establish whether there are changes in hemidesmosomal distribution during defined stages of chemical carcinogenesis in hamster cheek-pouch epithelium.