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The involvement of specific GEFs or GAPs in defined processes regulated by Rho GTPases makes them particularly suitable as therapeutic targets [ 150].
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However, a single snapshot of acquired genomic changes is inherently limited in defining processes important to the initiation, development, and progression of a particular tumor.
This recently established and presumably essential role of ISCs in previously defined processes of DNA repair, together with the known relevance of DNA-repair enzymes on tumour initiation, suggests that ISCs may be relevant for tumour suppression.
Most failures in this category can indeed be considered "bad". They usually involve deviations from spec in the closely defined processes of high-volume or routine operations in manufacturing and services.
"This is one of the more clearly defined processes in the law".
Model-based development of such applications aims to increase the integrity of these applications through the usage of explicit models employed in clearly defined process steps leading to correct-by-construction artifacts.
The main challenges of this method lie in well defined process temperatures during material deposition and forming, handling of the material during the processes, microstructure of the semi-finished matrix, and economical efficiency of the process chain.
Such an ensemble of genes is referred to as a functional module, and allows identifying and studying proteins likely involved in a defined process and their associations.
We tested this approach in cardiac surgery with defined process parameters that were regularly monitored.
There would, in short, be a clearly defined process for dealing with sovereign default.Yet the bankers remain appalled.
The variability in how organizations define processes makes it more difficult to contract for and communicate about them across companies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com