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The measure of effect used for all sub-studies is the proportional increment, defined as (increment in returns during the sub-study intervention period)/Goal.
Health states were defined by increments of ten letters in best-corrected visual acuity (BCVA), with a 3-month cycle length.
There were 17.5% of patients who had deterioration in physical function as defined by an increment of HAQ score of more than 0.2 at follow up survey.
There were 17 patients who had deterioration in physical function as defined by an increment of HAQ score of more than 0.2 at the follow up survey.> -wrap-foot> HAQ = Health Assessment Questionnaire.
Therefore, the conformers in each ensemble are sampled through clustering with the RMSD pred value, after rounding to the nearest 0.2 increment as defined in the following equation, RMS D cluster = int 0.5 + RMS D pred * 5 5 (4).
For purposes of this analysis, we defined quantiles in increments of 0.025, i.e. with each containing 2.5% of the mass of the distance distribution.
The refractive increment is defined as the increase in refractive index per one percent increase in the concentration [ 28– 31].
Expansion curves define the increment in permeability with increasing mean effective stress, and compression curves define reduction in permeability with increasing mean effective stress in the reservoir zone.
Non-invasive blood pressure monitoring (Finapres Medical Systems) was carried out continuously and the change in blood pressure was defined as the increment from the 7 beats immediately before transition to the 7 beats immediately after transition.
The maximum tolerated temperature was determined by raising the temperature in in 0.1°C increments until stable growth (as defined above) was no longer possible.
Exposure covariates were defined in seven day increments to maintain uniform exposure classification to the cohort analysis, and age and calendar year were adjusted for as continuous parametric variables defined during each seven day window.
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