Although these models are potentially useful for predicting interspecies transmission of influenza viruses, there is still a great difficulty in deciphering adaptation of viruses that show mixed signatures of both animal and human hosts.
We have specifically explored the use of structure-based phylogenetic relationships in deciphering functions of proteins belonging to this superfamily.
While methylation, acetylation, and ubiquitination have a role in many protein classes, major interest has developed in their role in the deciphering of the human "histone code".
Knockdown of overexpressed oncogenic miRNAs with the technology can be a rational therapeutic strategy for cancer, whereas inhibition of tumor-suppressive miRNAs by the sponges will be useful in deciphering functions of miRNAs in oncogenesis.
Our work provides new insights into the molecular mechanisms that govern Notch transcriptional activity and represents glimpse into NOTCH1 interaction landscape, which will help in deciphering mechanisms of NOTCH1 functions and regulation.
Such "targeted" metabolomic studies are quite useful in deciphering function of genes in system based approach [ 77].
Additionally, we show that in phenotypically overlapping disorders, leveraging protein-protein interaction data could prove useful in deciphering neighborhoods of mutated genes.
The zebrafish, Danio rerio, has been an effective tool in deciphering mechanisms of human GI diseases, due to the similarity in basic GI tissue structure, function and gene expression profiles (Stuckenholz et al., 2004; Stuckenholz et al., 2009).
Advances in structural deciphering of biomolecules that are involved in the pathogenesis of bone metastasis, such as OPG, integrins, and MMP, have allowed scientists to design molecules that mimic these critical targets [ 75].
Analytics are going to play more and more of a function in deciphering huge quantities of data, making sense of it, applying it into many different areas and then using blockchain technologies to securitize that.
