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I also mention in passing some of my personal links to research carried out in CSSS after its founding.
The percentage curcumin remained in C-SLN after 3 and 6 months was significantly more compared with that in CSSS (Fig. 2 in the ESM).
Mean pneumococcal density was compared in CSSs conducted before and after vaccination.
We first compared the DAFs of SNPs in CSSs to that of the flanking sequences.
The ASSSM will provide regional leadership and organizational support required to implement the program in CSSS.
An APDF is analyzed that expose behavior of the PLI for different amounts of noise in CSSs and epoch lengths.
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The reduction in fluorescence intensity with time in CSSS-treated cells suggests the possible efflux of curcumin with time and noncapability of sustained release (Ganta and Amiji 2009).
Significant reduction in drug levels were observed after 12 h in CSSS-treated cells compared with C-SLN (1.5-fold increase) and Tf-C-SLN-treated (2.5-fold increase) cells in quantitative evaluation.
ROS generation was found to be increasing with time in C-SLN and Tf-C-SLN-treated cells while in CSSS-treated cells the ROS generation became almost stagnant after 12 h substantiating the results of cell uptake.
One important observation from both dose and time dependent apoptosis study was detection of distinctly more late apoptotic/early necrotic cells (AnnexinV-FITC+PI+) than early apoptotic cells (AnnexinV-FITC+PI−) in CSSS-treated cells which can be attributed to the diffusion and accumulation of curcumin at high concentration directly at the site of action causing more necrosis.
At 2 μM curcumin concentration, percentages of caspase 3-positive cells in CSSS-, C-SLN-, and Tf-C-SLN-treated cells were 19.7, 32.4, and 51.2 %, respectively which increased to 26.7, 47.6, and 69.7 %, respectively, at 4 μM dose (Fig. 12).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com