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By contrast the degree of proteinuria in CRIC study was much lower (0.17 g/24 hours).
Further studies will evaluate whether hs-TnT is associated with adverse outcomes in CRIC.
In CRIC, 88% of subcohort enrollees had four or more urine collection periods, 6% had three, and 5% had two or fewer.
In CRIC, eGFRcys has a wider distribution of values than eGFRcr because enrollment was based upon a fixed range of eGFR [ 17].
Of the 3939 participants in CRIC, we included in our study only the 1423 patients who participated in sub-study of I-iothalamate clearance.
While FGF-23 does not appear to be a predominant factor for subclinical myocardial injury in CRIC subjects without CVD, it may yet prove crucial in the development of heart failure in this cohort via induction of LVH.
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The K/DOQI guideline recommended target of systolic < 130 and diastolic < 80 mm Hg [ 21] was achieved in only 17% of patients, less than that reported in the CRIC study (53%).
This is a prevalence of current smokers lower than that reported in the CRIC study, where smokers represented 14% of the total cohort [ 16].
In the CRIC study, male preponderance was also noted (54%) but the data is not completely comparable because in this study the goal was to have equal gender for study selection purposes.
The most likely explanation for the lesser degree of proteinuria may be related to the better BP control in the CRIC study where over 50% of the patients had achieved a BP < 130/80 mm Hg.
Serum creatinine measurements were done in the CRIC central laboratory at University of Pennsylvania on the Hitachi Vitros 950 calibrated to the MDRD central laboratory at Cleveland Clinic [ 15] (because the original 4-variable MDRD equation [ 16] was used as the entry criteria for CRIC).
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