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Furthermore, to test whether the mechanisms were associated with up-regulating of GLT-1, we used a GLT-1 specific inhibitor dihydrokainate (DHK) and analysis the expression of GLT-1 mRNA and protein in cortex of brain.
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18F-7B demonstrated labeling of Aβ plaques in cortex of AD brain sections and the binding to Aβ was inhibited in the presence of its unlabeled counterpart (7A) indicating specificity of the probe.
Our results can be interpreted by increased CRF1 expression in frontal cortex of brain which is related to appetite regulation following maternal preconceptional stress [ 40, 41].
Then we investigated whether presenilin was modified by nitrotyrosination in the prefrontal cortex of brain autopsy samples from AD subjects.
They localized a deficit of this enzyme in the frontal cortex of brain affected with AD, precisely one of its most affected regions.
DOI: http://dx.doi.org/10.7554/eLife.07860.015 10.7554/eLiFigure60.016 Figure 8 figure supplement 1. Cell-type specific effects in the cortex of brain-specific deletion of the paternal and maternal Bcl-x alleles.
As shown in supplementary material Fig. S5A,B, no APP695 protein was detected by western blotting analysis in the brains of wild-type mice, but high levels of expression were seen in the hippocampus and cortex of brains from 5XFAD mice.
We might call this "muscle memory" but really the memory resides not there, but in the cortex of the brain, in specialised structures that instruct our muscles precisely how to move.
The researchers had claimed that as the plant protein traveled between neurons, they could map out which neurons in the cortex of the brain received information from which smell receptors in the nose.
High-magnification images were acquired in the cortex of E15 brain slices by confocal microscopy and saved in a TIFF format.
Abnormalities in the cortex of the brain are often associated with alcohol-induced impairments in high-level sensory and motor processing, as well as with some FASD cognitive-behavioral phenotypes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com