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‡In continuation phase of treatment.
┼Culture negative at end of intensive phase; currently in continuation phase.
Below is a description of a male TB patient in continuation phase of treatment.
Tuberculosis treatment consists of two months intensive treatment under direct observation and six months treatment in continuation phase.
In continuation phase, category II patients received isoniazid, rifampicin, and ethambutol for 5 months (2H3R3Z3E3S3 + 1H3R3Z3E3 + 5H3R3E3) [ 5, 6].
Anxiety was significantly higher among patients who were in intensive phase of TB treatment than those of patients in continuation phase of treatment.
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It leads to stress and burn-out (participant 7)." Facilitating factors in the continuation phase in both models were: the increase in experience and expertise of case managers and an improved knowledge of the social chart.
Trials performed in the continuation phase in which patients who have achieved response after acute treatment are randomized to either continuation of the drug or a switch to placebo are suitable for assessing efficacy in the prevention of relapse of the index episode and switch to the opposite pole.
Impeding factors in the continuation phase in both models were: problems with structural financing after the care innovation funds were withdrawn; no clear agreements about the amount of non-direct client contact compared to direct, reimbursable client contact; and complicated registration systems for case managers.
Adherence was measured by recording clinic attendance and directly observed treatment (daily in the intensive phase and fortnightly in the continuation phase) and through interview and pill counts (in the continuation phase).
The rationale for the intermittent administration of drugs in the continuation phase is based on in vitro studies, which have suggested that antituberculosis drugs, particularly INH, demonstrate a significant and prolonged postantibiotic effect which permits an extended dosing interval (23).
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