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In order to annotate detailed functions in context of pathways underlying metabolism, cellular process, environmental information process and genetics information process, KEGG database was used (http://www.genome.jp/kegg/pathway.html).html
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Previously, a SNP ratio test (SRT) has been developed to assess enrichment of significant associations from GWAS in context of KEGG pathways [15].
Gene expression at different experimental conditions can be viewed sequentially in context of the pathway.
In context of RXR pathway, a number of genes were significantly overexpressed at the smallest ever studied exposure doses of BDE-47, 0.002 mg/kg BW.
Results of a filtering process can then be explored in the context of pathways in detail.
Another possibility is to use a systems biology approach, in which genetic alterations are evaluated in the context of pathways, networks and functional modules [ 5- 7].
Caleydo uses novel visualization techniques to support life science experts in their analysis of gene expression data in the context of pathways and functions of individual genes.
When observing experimental data in the context of pathways, a biologist is often interested in a subset path or route within a complex pathway map.
This approach, whose application in the context of pathways analysis is still largely unexplored, goes in a direction which can valuably complement approaches more extensively offered by the current literature.
This chapter presents a review of the state-of-the-art and perspectives of bioprocess design for biohydrogen production research in the context of pathways, microorganisms, metabolic flux analysis, process design, and reactor system.
Others have examined multidimensional data sets that include different genome-scale measurements simultaneously in the context of pathways [21], [22], [23].They apply statistical method to measure pathway enrichment and use gene-expression data to assess variation of pathway activity.
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