Sentence examples for in context of defects from inspiring English sources

Inhibitors of PARPs which interfering DNA repair, in context of defects in other DNA repair mechanisms, can thus be potentially exploited to inhibit or even kill cancer cells.

In this paper, a recent and more appropriate sub-asymptotic extreme value distribution is presented and discussed in context of defects.

We compare these results with those observed in laser irradiated and vacuum annealed samples, and then discuss these findings in the context of defects and defect complexes created during the high-energy heavy ion irradiation process.

Our candidate genes are lethal upon inhibition in the context of DDR defects, as depicted by their relatively higher essentialities specifically in DDR-deficient cell lines.

Biofunctionalization by neurotrophic factors for optimized nerve repair might also be a future option for the use of spider silk filaments in the context of peripheral defects.

Our method addresses this by identifying oncogenes in the context of DDR defects. 5.

Here, we only analyze expression up/downregulation and genomic amplification/deletion events affecting six DDR genes to study SL in the context of DDR defects.

In both analyses, we observe significantly higher essentialities for our genes in DDR-deficient cell lines, thereby indicating that knockdown of these genes is more lethal specifically in the context of DDR defects.

The thick junction concept is also gaining momentum in the context of mitigating defect and inhomogeneity issues.

In addition, a lack of simple and efficient algorithms for posterior computation has made more elaborate hierarchical Bayesian approaches appear unattractive in the context of software defect prediction.

Co-amplification of MYCN and GLI2 have been described previously in SHH medulloblastoma30,31,32 and, in the context of TP53 pathway defects, is associated with a very poor outcome33,34.