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This is an insidious process, seen in consistent changes in language.
Conversion of the forest to rubber plantation results in consistent changes in soil micro- & mesofaunal community composition.
Insulin infusion altered plasma concentrations of both TNF (P = 0.037) and IL-6 (P = 0.044), but did not result in consistent changes to either skeletal muscle or adipose tissue cytokine mRNA.
Third, in animal experiments amino acids or KAA are often loaded through drinking water, which does not result in consistent changes in the balance between amino acids and lipids.
However, inhibition with the prototype MEK inhibitor U0126 or the PI3K inhibitor LY294002 did not result in consistent changes in cellular bioenergetics (Beloueche-Babari et al, 2005, 2006), which may implicate other pathways in the effects observed with Orlistat.
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In contrast, consistent changes in levels of the AMPK-alpha1 and -alpha2 subunit (encoded by PRKAA1 and PRKAA2, respectively) were not observed with array data on samples obtained by laser capture microdissection.
Hierarchical clustering of the global transcriptional profiles and examination of changes in individual transcripts demonstrated consistent changes in gene expression in a majority of cases (N = 34).
An exception is prepubertal exposure to genistein: all the studies carried out, showing a reduction in mammary tumorigenesis in rats, also report consistent changes in mammary gland morphology.
By contrast, fluctuations of CR1 occurred upon small variations in transcript levels but in the presence of consistent changes in the subcellular and extracellular distribution of the protein.
The use of different sequencing platforms in this study was instrumental in confirming significant and consistent changes in transcriptional activity.
We do not know whether these developmental changes in weighting strategy reflect consistent changes in underlying multisensory mechanisms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com