Our data confirm that elevated serum IgG4 levels were found not only in IAC patients, but also in a considerable fraction (15%) of a large cohort of PSC patients, that the PPV of a sIgG4 in the lower elevated range between 1.4 and 2.8 g/L for IAC was only 28%, and that therefore serum IgG4 was insufficient to discriminate between PSC and IAC.
In addition, DYRK2 gene is amplified in a considerable fraction of cancers (Santarius et al., 2010) and its mRNA level negatively correlates with clinical outcome of breast cancer patients (Guo et al., 2016).
A high risk of bias in the flow component was observed in a considerable fraction of included studies.
In parallel with this observation, it was reported that the EGF-STAT1 signaling pathway, which is active in normal esophageal epithelial cells, is lost in a considerable fraction of esophageal cancer; furthermore, loss of EGF-STAT1 signaling was found to correlate with a worse clinical outcome [ 10].
T cells have been found to be decreased in a considerable fraction of patients, with a specific reduction in the numbers of naïve CD4+ cells (CD4+CD45RA+ cells) and naïve CD8+ cells (CD8+CD45RA+ cells).
The phase coexistence results in a considerable fraction of MnAs epitaxial films which are usually in paramagnetic phase at ~30°C, a strong limitation for room temperature spintronic devices.
This has also been demonstrated in human trials where vaccination with a recombinant tumor antigen in CpG/Montanide oil led to CD8 T cell response in a considerable fraction of the patients [51].
This data show that preferred orientation does change significantly in a considerable fraction of the cells when the contrast is modified, especially in the mixed contrasts condition.
The existing structural alerts identified many potential EA-EDs, but also resulted in a considerable fraction of false negatives with active EA-EDs not detected.
After transplantation, when kidney function is restored, appetite returns, patients gain weight, and, in a considerable fraction, NODAT follows.
