Rational design in conjunction with structure-based design led initially to the identification of anthranilic acid 5, an mPGES-1 inhibitor with micromolar HWB potency.
Results from high-throughput screening efforts have led, in conjunction with structure-based drug design, to the identification of highly potent and selective small molecule IRAK4 inhibitors from many diverse chemical series.
Sediment biogeochemistry was analysed in conjunction with structure and diversity of the nematode community and differences were tested between study areas, water depths (700 m vs 1000 m), stations, and sediment layers.
Second, studies of naturally occurring loss-of-function mutations in MC4R from obese subjects [23] [27], in conjunction with structure-function studies [28], [29], have identified several key regions of the receptor that are required for binding of the endogenous ligand, α-MSH.
This and various other methods that have been devised to identify functional residues in proteins, such as residue interaction graphs (Amitai et al. 2004) or statistical methods reviewed by Ahola et al. (2004) could reasonably be used in conjunction with structure-based alignment methods to determine reasonable alignments based on functional considerations.
We have used this assay in conjunction with cocrystal structures of small molecules to drive a structure-based design program aimed at the discovery and optimization of a novel class of potent Hsp90 inhibitors.
What's au courant is the cult of loving Airstreams as indoor and outdoor architecture: used alone or in conjunction with other structures.
Using selective immunopositivity of developing embryoid bodies to enolase, our obvious consideration was whether the surrounding tissues revealed immunoexpression of human chorionic gonadotropin in conjunction with these structures.
