Sentence examples for in compound development from inspiring English sources

Hence, in addition to supporting practical applications in compound development, activity cliff research is an area where chemoinformatics and medicinal chemistry meet.

Off-target activities are not unusual in compound development, and in the case of extra biological effects upon antigen presentation and cytokine function, could even be beneficial.

Their success hinges on biomarkers for identifying arrhythmogenic risk as early in the compound development process as possible.

TdP as a potentially drug-induced side effect on the heart has become a primary concern in drug development, so that torsadogenicity needs to be assessed and, if possible, excluded as early as possible in the compound development pipeline.

JMD designed and performed immunology and other in vivo experiments, analysed/interpreted data, and is actively participating in preclinical VBP compound development.

The earliest indicator used to assess torsadogenic risk in the pharmaceutical compound development process is usually based on the hERG IC50 value; compounds that block hERG too readily are discarded.

Many companies that manufacture this elastomer specialize in the formulation and mixture of elastomer compounds and focus in particular on fluoroelastomer-based compound development.

The class I KNOX genes are thought to play a role in compound leaf development in a number of species.

For example, several key morphological events in compound eye development are conserved, suggesting that this process is homologous among pancrustaceans [ 10- 18].

The class I KNOX genes are a family of homeobox domain-containing loci in plants that have conserved roles in promoting pluripotency in the shoot apical meristem and in compound leaf development [ 27, 28].

Using these modern techniques of data generation and analysis, together with established in vitro systems, it should be possible to predict subsequent adverse effects early in a compounds development.