"You have to understand the function of the gene and its products in a complex milieu, in a mouse or human not only a mouse or human, but many different mice and many different humans," he says.
Although multiple stresses affect islets in the complex milieu of diabetes, we demonstrated in vitro that lipotoxicity with the free fatty acid palmitate is sufficient to recapitulate the increase in Musashi and Hes1 gene expression.
In order to transmit signals with fidelity in the complex milieu of the cell, tight regulation of catalysis is required.
Although the function of LPLUNC1 remains to be resolved, our results suggest that the protein functions in the complex milieu that protects the mucosal surfaces in these locations.
Our results suggest that LPLUNC1 is an abundant, secreted product of goblet cells and minor mucosal glands of the respiratory tract and oral cavity and suggest that the protein functions in the complex milieu that protects the mucosal surfaces in these locations.
Finally, modelling demonstrates that the paradigm established from the kinetic-observations in dilute aqueous buffer do not always hold in the complex milieu of the cell.
Unfortunately, because the pathlength of light varies due to reflection and interference in a complex milieu of different tissues, absolute concentrations are difficult to estimate.
Together, these data would suggest that in the complex milieu of the retina, TRs may not remain bound to the rGH-PAL element, and that in the absence of high T3 a different factor(s) binds the sequence and recruits the appropriate co-activator components to drive reporter activity.
However, biomarkers are often very dilute in the complex milieu of human blood.
