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Lam et al. [2] found significant differences in complete blood count (CBC) parameters between survivors and non-survivors and between single and multiple trauma patients in 1,673 patients.
All animals were closely monitored for evidence of clinical illness (temperature, respiration, anorexia, dehydration, central nervous system disturbances, reduced activity and changes in behavior, and changes in complete blood count and chemistry) following NiV challenge.
There were no significant changes in complete blood count, liver function tests and renal function tests.
No changes in complete blood count, kidney function, or hepatic function were observed in any patient.
However, no significant change in complete blood count was observed in the W-13-treated animals.
No significant changes in complete blood count, body weight, or other appearances of toxicity were observed in the animals.
Similar(47)
The concept of detailed safety substudies is well established in endocrine therapy trials (Eastell et al, 2006; Coleman et al, 2007) and detailed toxicity monitoring was performed in the CALGB9344 trial in which complete blood counts were obtained two times weekly, and all toxicities of grade 2 or more were collected on the first 325 patients enrolled.
Leukocytopenia was defined as a continuous decrease lower than 4.8 × 10/μL in the number of white blood cells found in the complete blood cell count during treatment.
No clinically significant changes in electrocardiogram, complete blood count, basic metabolic panel, uric acid, liver enzymes, total protein, albumin, calcium or total bilirubin occurred during the study.
No remarkable abnormalities were found in the complete blood count and an ionized calcium of 1.91 mmol/L (reference range, 1.1-1.3 mmol/L) was confirmed hypercalcemia.
Other studies described this change in a complete blood count, with the same kinetics [8, 13, 35, 36].
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