Sentence examples for in complete blockade from inspiring English sources

Preincubation of ASC-8 with either NHK or HaCaT prior to incubation of cells on human laminin-1 (Figure 1c) or laminin-5-coated plates (Figure 1d) resulted in complete blockade of endogenous α6β4-laminin interactions.

In this study, both clopidogrel and ticagrelor treatment resulted in complete blockade of ADP-induced platelet activation, aggregation, and recruitment, and prevented platelet-mediated thrombosis.

Inhibition of p42/p44MAPKs activity with UO126 in BT474-HR and BT474 cells also resulted in complete blockade of MPA-induced c-Jun phosphorylation (Additional file 1: Figure 5), demonstrating the direct involvement of p42/p44MAPKs in MPA effects.

Fisher and colleagues (1996) found that pretreatment of UV irradiated excised (photoaged) skin with 0.1% tretinoin cream results in complete blockade of interstitial collagenase and gelatinases synthesis thus preventing collagen degradation.

Higher doses (100 nM) of endoxifen and 4HT, as well as a low dose (10 nM) of ICI, resulted in almost complete blockade of estrogen-induced proliferation in ERβ1-expressing cells but not in parental cells expressing only ERα.

Unfortunately, the use of these antiestrogens have undesirable side effects such as ICI 182,780 resulting in a complete blockade of activation pathways of ER and tamoxifen resulting in detrimental uterotrophic effects and can act as agonist for breast cancer cell growth [39], [40].

Fifth, coexpression of Shits along with dTrpA1 in DPMs, a manipulation that should not affect APL neurotransmitter release, results in a complete blockade of activation-induced sleep gains.

In essence, complete blockade of DNA-PKcs should certainly not be pursued as a therapeutic goal but bringing DNA-PKcs activity into a normal range may be all that is necessary to avoid the negative consequences of chronic DNA repair activity.

As in patient biopsies, complete blockade of efflux properties in the xenografts also required the combination of both inhibitors (Fig. 1E and Supplementary Fig. 3).

Three approaches were used to define a role for KLF8 in the induction of MDR1: (i) use of siRNA resulted in a nearly complete blockade of MDR1 induction acquired by hypoxia; (ii) luciferase reporter construct transfections were used to limit the hypoxia-responsive region of the MDR1 promoter; and (iii) ChIP assay was used to identify KLF8 binding sites in the MDR1 promoter.

The pesticide 1,1,1-trichloro-2-[ 1,1,1-trichloro-2-[ 1,1,1-trichloro-2-[ 1,1,1-trichloro-2-[ o-chlorophenyl]-2,2[ o-chlorophenyl]-2,2[ o-chlorophenyl]-2,2[1) of the cells tested.