The simulations also allow for a degree of protein flexibility during the encounter of the protein with PIP2; i.e., this method allows "dynamic docking" of PIP2 to the Kir channels over an extended time scale, with enhanced sampling in comparison with previous atomistic simulations.
The benefit of the ICAP study's proposed sample size, in comparison with previous studies of ALI/ARDS survivors, is most apparent when analyzing other patient outcomes.
In comparison with previous studies, our study has a large sample size of SNB- positive patients and in addition has also looked at gene expression in the primary melanoma to investigate prognostic biomarkers.
An advantage of our study, in comparison with previous research, was the use of a four-sample design including ADHD vs. ASD vs. ASD+ADHD vs. control.
Furthermore, at baseline, a higher rate of complete palsies (overall, 51%; Bell's palsy, 54%) in the study sample is obvious in comparison with previous retrospective studies, 7 10 and also higher than in recent prospective trials evaluating the efficacy of prednisolone and other drugs for Bell's palsy treatment, reaching values of less than 30 40%.
Further, despite the large sample size overall for each cancer site in comparison with previous studies, the numbers were small when the analyses were stratified on certain variables.
A pebble bed characteristic sample was also investigated in order to check the measurement accuracy in comparison with previous results.
In comparison with previous methods, we have achieved the photoluminescence enhancement efficiency of greater than 80% over the reference sample, which should be due to the silver nanoarray-induced localized SPR with a two-dimensional photonic crystal structural effect.
