Your English writing platform
Free sign upSuggestions(1)
Exact(4)
Our present genome-wide study indicates that pluripotent stem cells are generally hyper-methylated at promoter regions in comparison with differentiated cells.
These stem cell characteristics that are common to cancer cells suggest that fewer or different steps might be involved for stem cells to transform into tumour-initiating cells in comparison with differentiated cells.
When compared to EPI-7 cells, an epithelial derivative of P19 cells, the undifferentiated P19 EC cells were found to be less sensitive with respect to the induction of 6-thioguanidine resistance (6-TGr), suggesting a higher or more efficient DNA repair capacity of undifferentiated in comparison with differentiated cells.
Consequently, cytotoxicity assays based on the reproductive integrity of cells (=clonogenicity) after application of mutagenic chemicals (ENU, MMC and MNNG) were established by using murine EC, EG and ES cells: a higher sensitivity of mEG cells in comparison with differentiated EPI-7 cells was detected, whereas both mEC cells and mESCs were less sensitive (Sehlmeyer et al. 1996b).
Similar(56)
We first analysed sialidase expression in GSCs and we identified a significant increase of NEU4 expression in comparison with more differentiated GBM cells.
In comparison with healthy and differentiated cells, cancer cells frequently rewire their mitochondria to switch from a maximal energy production by means of the mitochondrial electron transport chain to a well-adjusted balance among constant energy requirement.
Glioblastoma (GBM) stem cells (GSCs), responsible for tumor growth, recurrence, and resistance to therapies, are considered the real therapeutic target, if they had no molecular mechanisms of resistance, in comparison with the mass of more differentiated cells which are insensitive to therapies just because of being differentiated and nonproliferating.
For comparison with differentiated cells, Santoni et al. also obtained the 2010 data on corresponding HeLa-S3 cells and found that "HERV-H expression is barely detectable in HeLa", although it was identified when using transient-transfection assays [ 30].
Glioblastoma (GBM) stem cells (GSCs), responsible for tumor growth, recurrence, and resistance to therapies, are considered the real therapeutic target in comparison with the mass of insensitive and differentiated tumor cells [ 1].
Additionally, patients with advanced-stage tumors and poorly differentiated tumors had a shorter time to cancer progression in comparison with those with early-stage tumors and well differentiated tumors.
In general, all miRNAs classified as neuronal or astrocytic in the NT2-N vs. NT2-A comparison were also differentially expressed in one, or both differentiated cells data sets in comparison with NT2-28D (Fig. S1C).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com