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Exact(6)
Due to the difference in comparators across the trials (infliximab-biosimilar is compared to infliximab in the PLANETAS study, while other biologicals are compared to placebo), traditional methods cannot be applied for the comparison.
Terminating person-time in comparators at the matched PC patient's death or loss to follow-up resulted in comparable person-time up to 30 months of follow-up and lower person-time among comparators thereafter.
Overall, using multivariate analysis, the risk of gametocyte carriage by Day 14 was lower in comparators than in DP groups (P = 0.002, stratified by site)(figure 3, table S2).
30 day mortality was high in both groups (30% in care home patients and 24% in comparators).
The cumulative incidence density of cancer in the rosiglitazone group was significantly (P < 0.05) lower than that in comparators (0.23 [95% CI 0.19 0.26] vs. 0.44 [0.34–0.58] cases/100 patient-years; P < 0.05).
Secondly, steroid injections were compared to placebo but also to other commonly used treatments ("wait and see", NSAIDs, physiotherapy) and this heterogeneity in comparators was taken into account, leading to sensitivity analyses.
Similar(54)
No extrapyramidal reactions were reported in the granisetron group compared with 13 in comparator-treated patients (8%).
Sneed et al. [ 23] also found higher response rates in patients in comparator trials (60% response) compared with placebo-controlled trials (46% response).
Impact – Clients of both project noted positive interactions with health workers using the eMNH and eNutrition tools compared with the experience of clients in comparator sites.
"It is really a matter for the OECD exactly which people have been in comparator tests, but the OECD has verified that Shanghai is three years ahead of the UK and Singapore is two years ahead".
However, as Table 3 shows, business interest rates are significantly higher than in comparator countries.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com