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The new approaches hold great potential for efficiently selecting a more effective treatment in comparative trials.
The aim of the present paper is to test whether placebo has indeed helped establish equivalence of effect in comparative trials of new antidepressants.
However, with the only exception of a head-to-head randomized trial versus sumatriptan [10], frovatriptan efficacy had never been tested in comparative trials with other triptans.
The intervention doses obtained could be particularly useful in comparative trials.
The favorable results for telithromycin in the present study are consistent with those reported previously in comparative trials.
It could be particularly useful in comparative trials and in studies of the influence of implementation on programme outcomes.
Similar(39)
Similar composite endpoints may also be useful in future comparative trials in antifungal prophylaxis.
HAART regimens containing abacavir have been shown in direct comparative trials in HIV-infected patients with a baseline viral load <100,000 copies/mL to be as effective as nelfinavir-and indinavir-containing HAART in suppressing viral load and increasing CD4+ cell counts without inducing hyperlipidemia, insulin resistance, or central adiposity [ 18- 21].
It would be preferable that every drug (and indeed every dose and every formulation [ 36]) be evaluated in randomized comparative trials with active comparators from the same class for their effects on clinically important outcomes.
In three comparative trials silymarin has been tested against placebo, in one against vitamin E, and in one against pioglitazone and metformin (Summary in Table 4, [98 102]).
The role, if any, of antimicrobial prophylaxis for GI endoscopic procedures in prosthetic joint patients has never been addressed in prospective, comparative trials.
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