The binding of blockers to the human voltage-gated Kv1.5 potassium ion channel is investigated using a three-step procedure consisting of homology modeling, automated docking, and binding free energy calculations from molecular dynamics simulations, in combination with the linear interaction energy method.
In the first run, we imposed a K48-diUb linkage in combination with the ambiguous interaction restraints (AIRs) defined from the CSP data.
These functions were not predicted by orthology alone but only in combination with the conserved interaction neighborhood of EPHB4.
We also used the AtGenExpress data [ 40] in combination with the protein interaction information to extract protein sets in tetramer-like subgraphs for which the encoding genes are jointly expressed in at least one Arabidopsis tissue.
The captured data using the camera can identify the physical interaction in combination with the given digital interaction information.
This in combination with the intermolecular π π interaction result in the formation of one-dimensional nanostructures with rod shaped morphology.
Using the software package "Cytoscape" in combination with the "Michigan Molecular Interactions" (MiMI) plugin, we searched the list of 193 genes that are differentially regulated in DLD1, SW480, and LS174T cells for known interactions.
In combination with the group contribution based interaction parameter computation method (PPR78) developed by Jaubert et al., it has the potential to predict the phase behaviour of mixtures containing ill-defined hydrocarbons such as bitumen and heavy oil.
Interactivity lets us leverage 'play,' this special mode of processing of our experiences, in combination with the 'game logic.' Interaction provides the draw for a curious and playful human nature engaging inevitably in the exchange, in the process of learning and inferring.
4 This, in combination with the negligible expected drug interactions, and the advantage of once-daily dosing, 15 has led to an increasing interest in the potential use of this AED for epilepsy therapy in the elderly.
