In combination with the constraint (sum _{j,k} p_{ijk}=1) for a given i, maximizing (3) with respect to the cell probabilities leads to the maximum likelihood estimator for the cell probabilities: widehat{p}_{ijk}=frac{n_{ijk}}{n_{i}} text{for} i, j, k=0,1.
In combination with the membrane constraint, proteomic predictions represent a milestone for constraint-based modeling.
Whether such a pattern also applies to metatherians, possibly in combination with the geographic constraint hypothesis discussed further below, is a promising avenue for future study that will benefit from a broadening of focus beyond comparisons of carnivorous fossil metatherians.
These assignments allowed a total of 2634 distance constraints (Table 1) to be unambiguously derived and these were used in combination with the dihedral angle and hydrogen bond constraints to calculate the solution structure of the N terminal 135 residues of the hERG K+ channel (Fig. 1).
The multimodal distributions with evidence for equidistant intervals, in combination with the observation of MSR-specific constraints on minimum array size, suggest that MSRs are limited in their configurations and that deviations thereof may cause disease, as is the case for facioscapulohumeral muscular dystrophy.
In particular, in both [3] and [32] authors emphasize several factors that, in combination with the uneven distribution, impose harder learning constraints.
Reasons for euthanasia during surgery included financial constraints, often in combination with the relevant prognosis.
This in combination with the increased number of product variants makes it necessary to base discrete lot-sizing models on an accordingly shorter period length which in turn causes a significant increase in the number of variables and constraints.
