Also, the rate and extent of absorption from lung after inhalation was shown to be well predicted by deposition pattern in combination with the expected rate of mucociliary clearance and rate of dissolution in situ as simulated by a computer based mechanistic model.
The good agreement in combination with the expected high oxygen saturation indicates that all fitted parameters are correct and that quantitative determination of hemoglobin chromophores is possible.
This result also provides a plausible explanation for the unexpected result using the p-trifluoromethyl-substituted homoanhydride with -oxaziridine 5, with epimerisation at C 5) in combination with the expected mixture at C(2) leading to the observed drop in ee of both diastereoisomers of 25 (Table 2).
The analysis of HAQ CFB at 24 weeks and 52 weeks showed that abatacept in combination with MTX is expected to be more efficacious than MTX monotherapy and is expected to show a comparable efficacy relative to other biologic DMARDs in combination with MTX.
The benefits from the fusion of fDOT and PET in combination with CT are expected to give rise to scanners where the two modalities are integrated within the same apparatus, and there are ongoing efforts for the development of this type of methods [34 36].
Moreover, with the introduction of the HIV integrase inhibitor dolutegravir, use of ABC in combination with 3TC is expected to increase in the future.
Abatacept in combination with MTX is expected to result in a comparable change from baseline in HAQ score and comparable ACR-50 and DAS28 < 2.6 response rates in MTX-IR patients compared to other approved biologic agents.
4 This, in combination with the negligible expected drug interactions, and the advantage of once-daily dosing, 15 has led to an increasing interest in the potential use of this AED for epilepsy therapy in the elderly.
Genotyping for pharmacogenetic polymorphisms will provide additional information on the individual drug metabolizing capacity, and sometimes also information on drug efficacy, and if performed in combination with TDM, we expect further insights into the specific requirements for drug therapy of these patients.
The recovery of PHAs requires the disruption of valuable biocatalysts of bacterial cells, while the production of secreted materials, such as RLs, in combination with PHAs production is expected to enhance the availability of biocatalysts because the cells can be used as "microbial cell factories" for the production of the exo-products before the eventual disruption to recover PHAs.
