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Ribavirin may also be used in combination with agents known as sofosbuvir and velpatasvir, which inhibit key molecules involved in HCV RNA replication.
Infection with chloroquine-resistant P. falciparum may be treated with quinine sulfate, often in combination with pyrimethamine and sulfadoxine, or with artemisinin, in combination with agents such as mefloquine or amodiaquine.
A formal model of wireless sensor networks in combination with agent-based simulation model is presented in (Niazi and Hussain 2011a, b).
Whether low dose IM in combination with agents of distinct but related mechanisms could be one of the strategies to overcome these concerns warrants careful investigation.
In line with this, bisphosphonates are demonstrated to be particularly effective at reducing breast tumour growth when used in combination with agents that directly target cancer cells.
These compounds could be developed in combination with agents such as paclitaxel, gemcitabine or vinorelbine in patients with advanced and/or refractory solid tumours.
3, 4 Similarly, in patients with advanced gastric carcinoma, capecitabine has been used successfully as first-line therapy in combination with agents such as cisplatin.
These findings are important for future clinical trial design with MDM2 p53 antagonists when used in combination with agents that are MDR-1 substrates.
DCA has been reported in several studies to be most effective when used in combination with agents that inhibit mitochondrial function.
Panobinostat (LBH-589), a cinnamic hydroxamic acid targeting multiple HDACs, is undergoing phase III trials in combination with agents including bortezomib and dexamethasone in relapsed and refractory MM.
The potential for capecitabine to be used in combination with agents that upregulate thymidine phosphorylase in relapsed ovarian cancer is clear.
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