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In combination, therefore, Bcl-xL and Mcl-1 neutralize all proapoptotic Bcl-2 proteins.
We have investigated the effects of ZOL and PAC on ECs in vitro, both alone and in combination, therefore determining the effects on EC death and the ability of ECs to adhere onto membranes of various components of the extracellular matrix as well as on EC proliferation, migration and Rap1a prenylation.
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The amplitude combination therefore falls in magnitude as Ω differs from θ, equation (4), and when θ differs from the perfect constructive interference combination of waves, A 2θ.
In most previous studies, the authors do not provide details about the rates of each aberration in patients with the 11q-/13q- 11q-/13q-on, therefore the discombination betherefore primary and secondary eventhes not possible.
Analyzing these alterations in combination may therefore provide deeper insight into the pathobiology of the disease, while also generating panels of markers that may be able to better predict patient outcome and treatment response.
The therapeutic doses of PARPi in combination studies, therefore, are expected to be lower; this has not always been the case with PARPi combination trials and may underlie the toxicities noted with the latter.
Furthermore, many studies reporting significant associations with biomarkers have assessed fruit and vegetable intake in combination only; therefore, it is unclear whether a particular dietary component is driving the associations.
Any increase in the dose of ARBs in combination therapy may therefore lead to an even higher incidence of adverse effects without further benefit.
Thus the tubule phenotype we observe relies on the activity of these domains in combination and is therefore distinct from that observed with Shigella toxin [29].
In combination, we were therefore able to examine in greater detail how carotenoid availability and plasma testosterone levels may interact in their effects on song behaviour in European starlings.
Monotherapy in RA (infliximab-biosimilar can be administered only in combination with MTX; therefore, only combination therapies were compared).
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