Although the possible mechanism is not known at present, the administration of these two physiological substances in combination represents a highly effective and safe alternative for the treatment of knee OA.
3 Recent experience with nivolumab and ipilimumab suggests, however, that there is a possibility for tolerability concerns as well. 2 Accordingly, selection of the appropriate dose and schedule of CIT when given in combination represents yet another consideration to realize the full therapeutic potential.
The issue presented was whether the changes West makes to an opinion, either singly or in combination, represent a sufficient creative effort to warrant copyright protection.
Results of EFA indicate that five factors in combination represented test takers' attitude to the VET.
In this paper we illustrate how two types of analysis might, in combination, represent a viable approach.
Thus, these strategies in combination represent a highly logical and synergistic approach for the management of CPM.
We previously identified a number of genes upregulated in PCa, which when used in combination represent useful biomarkers for detection of this disease (Landers et al, 2005).
The average final yields of diplopterol, 2Me-diplopterol, BHT, and 2Me-BHT were 3 mg, 53 mg, 11 mg, and 24 mg, respectively, which in combination represent ∼3% w/w of TLE.
The most common cancers were leukaemias (32%, with 81% of these being lymphoid leukaemias), tumours of the central nervous system (CNS, 22%) and lymphomas (10%), which in combination represented nearly two-thirds (64%) of all cases.
24 25 Our results suggest that trials conducted in populations with peripheral arterial disease should consider including other vascular events as outcomes, particularly heart failure, atrial fibrillation, and chronic kidney disease (which in combination represent more than half of initial vascular events among those with peripheral arterial disease).
Using this approach, we were able to interpret data on relatively small fold changes in gene expression, which may on their own be of limited importance but, in combination, represent multiple hits to specific pathways and may thereby affect, for example, mitochondrial function.
