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Therapies directed against subclonal variants in DIPG and mHGG, such as PDGFRA, should not be abandoned but rather pursued in combination instead of monotherapy.
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Otherwise, the results of the meta-analysis may inadequately explain heterogeneity in the included trials due to confounding by the differential presence of undetected or unlabelled components in certain component combinations instead of others, or the presence of effect modifiers that could meaningfully explain heterogeneity.
In addition, modelling of drum combinations instead of detectors for individual drums was investigated, but found not to work very well.
Too often life is like this and I get stuck puzzling over numbers and combinations instead of enjoying the experience or being in the moment.
Taguchi's method tests pairs of combinations, instead of having to test all possible combinations (as in a factorial experimental design).
In fact, this is another important argument supporting the idea of using markers combinations instead of taxa.
However, the treatment of severe refractory cases still remains a major challenge for clinicians in which combination therapy instead of monotherapy maybe a better choice.
In combination with subsampling instead of bootstrap sampling, the splitting criterion of cforest has been reported to be less biased than the RF criterion [ 105].
Adequacy could be achieved by many different methods in combination with, or instead of, dialysis.
As discussed in the present review, adequacy could be achieved by many different methods in combination with, or instead of, dialysis.
Linked to this, it is apparent that many people seek traditional remedies, in combination with or instead of recommended evidence-based treatments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com