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Time spend in closed arm (sec) Mean ± S.E.M.
It also reduced immobility time in forced swim test and time spent in closed arm in elevated plus maze test.
The average of time spent by these positive control group mice were 107.0 ± 12** sec in open arm and 169 ± 13.1** sec in closed arm respectively.
The average of time spent (sec) by the group IV mice treated with extract dose 400 mg/kg body weight was more significantly (p < 0.01) increased in open arm and decreased in closed arm by 149.2 ± 27.63** sec and 150.8 ± 27.63**sec respectively when compared to control.
However, the lack of a change in closed arm entries suggests that the change in open arm behaviour cannot be explained solely by altered locomotor activity.
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The time spent in closed arms and open/closed arm entries were recorded.
Time spent in closed arms differed significantly between the four groups, F 3,39) = 2.89, p < .05.05
Simultaneously, the distance travelled in open arms was also significantly decreased and distance in closed arms was significantly increased in HCD group.
Specifically, females spent more time in open arms and less time in closed arms than males (individual data for females and males not shown).
The number of entries into open and closed arms, time spent in open arms and time spent in closed arms were measured and %time in open arms (related total time 420 s) was calculated.
In young rats, it showed a significant increase in time spent in open arms and a significant decrease in time spent in closed arms in HCD group compared to control group.
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