Mutations in the first JunB-binding site (closer to transcriptional initiation site) and the second binding sites resulted in clear reduction in reporter gene activities, whereas mutations in the third or fourth JunB-binding site gave rise to negligible effects on the JunB-mediated transactivation of the IRE1a-specific reporter gene.
The here described antitumoral activity of the scFv scTRAIL fusion protein, which resulted in clear reduction in tumor size under treatment, appears superior to that of published preclinical data with homotrimeric TRAIL, regarding both the applied dose and the treatment periods.
PRRSV-2 vaccination resulted in a clear reduction in viral load in serum after PRRSV-2 challenge, whereas there was limited effect on the viral load in serum following challenge with the PRRSV-1 strains.
Nonetheless, even though the absence of Fur or a decrease in the iron concentration resulted in a clear reduction in hilD expression (Figure 5), both HilD and Fur appear to be necessary for full in vivo expression of the gene.
The activity of M. pulcherrima in mixed oxygenated cultures resulted in a clear reduction in ethanol yield, as compared to S. cerevisiae.
The article, The National Emergency Access Target and the 4-Hour Rule: Time to Review the Target, directly linked the NEAT with clear reductions in in-hospital mortality of emergency admissions.
INH treatment resulted in a clear reduction in lung size and lesion size in all treatment groups.
After confirming that CalpA mRNA levels were decreased by CalpA RNAi expression (CalpA KK101294 from the Vienna Drosophila Resource Center, expressed in eyes using GMR-GAL4) in heads of flies expressing Httex1-Q46-GFP, we observed that decreased CalpA levels resulted in a clear reduction in the number of Httex1-Q46-GFP aggregates in the eye, relative to the control flies.
Colony formation assay further showed that downregulation of GOLPH3 in two tested cell lines with transfection of GOLPH3 siRNA resulted in a clear reduction in the colony formation capacity compared with the control siRNA-transfected cells (P<0.01; Figure 6B).
Evaluations of the impact of total bans on smoking in other countries have shown clear reductions in SHS exposure and improvements in the respiratory health of hospitality workers [8] [18].
