Exact(46)
(e) Venn diagram of the overlap between the responses in chaperone deficient strains, Coa3-null mutants, and the CCCP-treated wild type cells.
We find that the decline in chaperone activity in each compartment results in loss of respiration, demonstrating the dependence of mitochondrial activity on cell-wide proteostasis.
More specifically, analysis of the mitochondrial volume using MitoLoc ImageJ plugin revealed a distribution shift towards smaller volumes in chaperone deficient mutants relative to the wild type.
Furthermore, uncoupling of the respiratory chain with CCCP yielded a response partially overlapping with the response observed in chaperone deficient mutants.
We found that mitochondria in chaperone deficient strains are smaller and more round than the tubular mitochondria found in WT, which is indicative of mitochondrial fragmentation (Fig. 3b).
Click on a gene's description to view its network relationships with genes known to be involved in "chaperone mediated protein folding requiring cofactor".
Similar(13)
Lamp2a plays a critical role in chaperone-mediated autophagy.
Cuervo, A.M. & Dice, J.F. Age-related decline in chaperone-mediated autophagy.
This review provides an update on the recent successes in chaperone-assisted crystallography.
LAMP-2 also functions in chaperone-mediated autophagy [16] and immunity [17].
The ubiquitin system also regulates signaling proteins controlling cell metabolism, cell cycle, and ion channel turnover, and is involved in chaperone-mediated myosin assembly [27] [30].
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